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The SEN method only considers purely epistatic interactions, i.e., it measures the effect of the interaction outside of the individual main effects of the interacting SNPs.
Importantly, changing the mitochondrial background alters the effects of the interacting nuclear genes without changing the nuclear gene sequence.
Another notable finding is that the main effects of the interacting SNPs affect their likelihood of being detected at low false positive SNP counts by most methods.
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The growth-promoting effect of the interacting loci was highly dependent on the genotype at Growth9 as HWS homozygosity at this locus was required for the other interacting loci to have a significant effect on growth.
However, in the IWA6988 × IWA167 interaction, the presence of the susceptible alleles from one of these two loci was associated with a reduction or elimination of the effect of the interacting locus.
Most of the symptoms and signs of scorpion envenomation have been attributed to the effects of the venom interacting with sodium channels and of neurotransmitters released from autonomic nerve endings [9, 10].
The primary reasons for this are the small-diameter (1 mm) cannula and the effects of the laser interacting with tissue.
But there are no reports about the effects of the nitrogen interacting with high temperature on spikelet fertility in rice production.
Nevertheless, when effect size is measured simply by comparing overall liability marker scores for those with the risk and nonrisk versions of the gene, the effect sizes of the interacting genes were small.
In other words, prior experience with MT and the effects of the retreat interacted with each other.
This three-way statistical interaction corresponded to distinct effects of the sex of interacting mice on SI responses, which gradually came to overshadow the strain-dependent influence during late adolescence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com