Sentence examples for effects of such variants from inspiring English sources
It may be that a larger sample size may be required to fully elucidate the effects of such variants in individuals with severe or refractory cachexia.
Although assessment of the pathogenetic effects of such variants is challenging, the effort required is justified because successful results are crucial to offer definitive diagnoses and conclusive genetic counseling, when establishing genotype-phenotype correlations and in view of future therapies.
Since genetic variation may contribute to AKI susceptibility [ 30], this hypothesis warrants future studies of KLK1 promoter variants in larger cohorts, assessing the effects of such variants on both susceptibility and recovery in AKI, since exogenous KLK1 does exert protective effects against aminoglycoside-induced AKI [ 7, 8].
Overall, available evidence suggests that the influence of a genetic variant on longevity may be negative, neutral or positive, depending on a delicate balance of the detrimental and beneficial effects of such variant on multiple health and aging related traits.
We also do not know whether segregating genetic variation that affects gene expression is common or rare, how the effect sizes of such variants are distributed, or whether they carry a signature indicative of natural selection.
Currently, demonstrating an actual effect on gene function of such variants is limited, but will be of importance as improving sequencing technologies provide larger amounts of variant data.
The numbers of such variants, their allele frequencies and the strength of their effects is not known.
MRCP can assist detection of such variants when suspected clinically.
The ready availability of genomic and genetic information generated by high-throughput sequencing allows the application of advanced bioinformatic methods to characterize the quantity and distribution of the small and structural variants, and so clarify the effects of such genomic variants.
Finally, we did not evaluate the effect of common environmental exposure on the associations between the genes of the immune pathway and wheezing but, as it has been suggested that environmental exposure may modify the effect of such genetic variants on disease susceptibility, an analysis of gene-environmental interactions is necessary before drawing any definite conclusions.
