Here too, we are following a strategy that uses reconstituted systems to monitor function, in correlation with high-throughput mutagenesis to survey the effects of sequence variation.
However, little is known about oligomerization effects of sequence variation in other residues within the Aβ linker region.
Spo0F and the N-terminal receiver domain of NtrC (NT-NtrC) have similar topologies but low sequence identity, enabling a test of the effects of sequence on folding.
A procedure was used that was derived from variations of the Corsi test, designed to test the effects of sequence structure and movement path length in humans.
The effects of sequence distribution of two types of poly(propylene-ethylene) (PP-PE) copolymers, with propylene being the dominant component, on the associated crystallization behavior have been analyzed.
Experiment 1 (N = 30 MU + 30 nonMU) revealed effects of sequence length and timbral dissimilarity of items, as well as an interaction of musical training and pitch variability: in contrast to musicians, non-musicians' performance was impaired by simultaneous changes in pitch, compared to a constant pitch baseline.
By quantifying and rationalizing the contribution of key motifs to transmembrane helix association, our work offers a route to direct the design of novel sequences for use in biotechnology or synthetic biology (e.g. molecular switches) and to predict the effects of sequence modification in known transmembrane domains (for control of cellular processes).
Effects of sequence variation on differential allelic transcription factor occupancy and gene expression.
In addition, these results suggest caution in the interpretation of data solely obtained with minigene constructs to study the effects of sequence variation on splicing.
Moreover, the long range effects of sequence variation have emerged as a general property of many proteins [51] [53].
This system facilitates the stuffy of the effects of sequence divergence as it does not cause massive aneuploidy.
