Separating effects of seizures from effects of neurological dysfunction on behavior problems, however, will be difficult even in prospective studies of children with new-onset seizures.
In the current study we extend these observations to subject self-report of preference for lamotrigine or topiramate independent of potentially confounding effects of seizures or seizure control.
Hilar parvalbumin-expressing interneurons were more sensitive to the effects of seizures than somatostatin-stained hilar interneurons or hilar mossy cells.
Neuropsychology plays a vital role in the treatment of epilepsy, providing information on the effects of seizures on higher cortical functions through the measurement of behavioral abilities and disabilities.
The role of seizures in the development of these problems is not known primarily because of difficulties in separating the effects of seizures from the three other potential causal factors: (a) poor child and family response to the condition, (b) side effects of antiepileptic medication, and (c) neurological dysfunction that causes both the seizures and the behavioral problems.
It is not yet clear, however, whether the epilepsy is usually caused by hippocampal abnormalities or whether the hippocampus is damaged by cumulative effects of seizures.
We have used this in vitro model to study the effects of seizure-like activity on the NVU.
DOI: http://dx.doi.org/10.7554/eLife.01267.007 Specifically, the effects of seizure-induced increase of NRSF levels on NRSF binding to the chromatin correlated with the degree of repressor binding in the naive state: binding of NRSF to certain genes (Ep300, Hcn2, P2xr5, Xpo6) was modest and did not increase significantly upon seizure-induced increase of NRSF levels (white columns of Figure 5A C).
Dysembryoplastic neuroepithelial tumors (DNTs) provide a unique model for studying the effects of seizures on cognitive development.
