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In contrast to few single loci exerting large effects on some phenotypes – mostly immune-related traits – the majority of traits was only associated with loci displaying small effects of odds ratios ranging from 1.1 to 1.5 [ 2].
In contrast, the effects of odds ratios obtained with regular regression analysis (either significant or not) on the outcome of interest are entirely dependent on the prevalence of the outcome, and the clinical value is difficult to disentangle (and often disappointingly low).
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It also had a moderate (but non-significant) effect on odds of binge drinking.
The SNP that was most strongly associated with sustained virological response was rs12979860, with an effect size of odds ratio (OR) = 3.77, based on meta-analysis of 42 studies.
Our control datasets (A1, 485 controls vs. A2, 735 controls) had 99% power to detect the effect size of odds ratio = 0.4 (α = 0.05) for age, previously reported by Reveille and colleagues [ 9].
Table 2 expresses predictor effects in terms of odds ratios (exponentials of logit coefficients), interpreted as multiplicative effects on the odds favoring renewable energy development, or anthropogenic climate change, per 1-unit increase in each predictor.
In this paper we use a combination of theoretical and simulation results to estimate the mean and variance of Q when the effects are logarithms of odds ratios.
A meta-analysis supported the evidence of the obesity-protective effect of MC4R Leu251 (odds ratio = 0.52) [14].
The reported nonsignificant detrimental effect of ET (odds ratio, 0.84) had a wide 95% confidence interval of.44 1.60 (crossing unity).
Compared with placebo, the magnitude of treatment effect of bupropion (odds ratio 0.51, 95% confidence interval 0.36 to 0.73) was similar to that of nicotine replacement therapy (0.57, 0.48 to 0.67).
Diet had a very strong association with depression risk, both clinically and statistically, with a clear dose-response effect of increasing odds of screening positive for depression with worsening diet.
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