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In particular, MEAs have been applied to explore the pharmacological and toxicological effects of numerous compounds on spontaneous activity of neuronal and cardiac cell networks.
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It has been shown that Cs may affect the PK of numerous compounds through its inhibitory effect on CYP3A4 or OATP transporters (11, 12, 17– 17).
Off-target interactions are typically related to adverse drug effects, among which a prominent example is the interaction of numerous compounds with hERG, a potassium ion channel expressed in the heart and in nervous tissue.
Zebrafish (Danio rerio) have emerged as a promising new animal model to screen the effects of numerous psychotropic compounds.
The Yale team took advantage of the short lifespan of yeast to test the effects of numerous chemical compounds on the lifespan of Saccharomyces cerevisiae, a yeast used in winemaking and baking.
These may cross-react to a minor degree with the oestradiol antiserum but their concentration and the sum effect of numerous such compounds can lead to substantial biases.
Phytochemical studies have shown the presence of numerous valuable compounds, such as volatile compounds, flavonoids, phenolic compounds, fatty acids, and amino acids.
They envision the MINC assay as part of a suite of cell-based tests that together could be used to quickly assess numerous potential toxicologic effects of chemical compounds.
He prepared numerous compounds of this new element and investigated its properties.
Numerous trials have been or are currently being conducted to determine effects of various compounds on AD in different stages.
The BV is composed of numerous bioactive compounds, which may have different effects depending on the site of application, even at the same dose [ 8, 9, 14, 23].
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