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This distribution can also be biased by mutational hot spots and differences in fitness effects of mutations in the gene involved.
Effects of mutations in several charged residues within the Aβ linker region on aggregation have been extensively studied.
(B and C) Effects of mutations in the ATRX1,253 1,326 (B) and DAXX55 144 (C) on the interaction between DAXX and ATRX analyzed by ITC assays.
Thus, it was shown that the synergistic effects of mutations in only two regulatory genes, acrR and marR, can significantly increase organic solvent tolerance in E. coli.
To successfully design new proteins and understand the effects of mutations in natural proteins, we must understand the geometric and physicochemical principles underlying protein structure.
By examining the effects of mutations in the fruit fly's DNA, researchers have gained insights into everything from aging to addiction.
We have leveraged the CRISPR/Cas9 genome editing techniques to characterize the effects of mutations in oculocutaneous albinism II (oca2), a candidate gene hypothesized to be responsible for the evolution of albinism in A. mexicanus cave populations.
Direct methods, which use global statistical models of sequence coevolution, have enabled the prediction of membrane and disordered protein structures, protein complex architectures, and the functional effects of mutations in proteins.
The locomotor effects of mutations in the ubiquitously-expressed Drosophila lam gene thus appear similar to some of the effects of mutations in the human LMNA gene.
We further analyzed the effects of mutations in Hh signaling related genes.
These effects are similar to effects of mutations in the mammalian LMNA gene.
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