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Effects of linkage barriers result into poor sales forecasting.
The conclusion is therefore that parameter independence is important when the effects of linkage parameters are calculated using SDA.
The elements to be considered include the applicability of a family-based linkage paradigm versus a population-based association design and the effects of linkage disequilibrium (LD) and genotypic relative risk (GRR).
In the current study, we evaluated the effects of linkage of human papillomavirus (HPV) type 16 E7 as a model antigen to N-terminal and C-terminal of glycoprotein 96 (NT-/CT-gp96) on the potency of E7-specific immunity generated by DNA vaccines.
Application of ILIR can be useful during marker selection and design of new marker panels, as well as being highly relevant for existing marker sets as a way to properly evaluate the effects of linkage on a case-by-case basis.
Thus, inherently, this approach does not account for the effects of linkage on synonymous sites.
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Kreitman and Wayne have proposed a selective model for intron presence associated with the deleterious effects of linkages between sites under selection, a phenomenon termed Hill-Robertson effect.
Until now, the specific effects of linkage-derived genetic load have not been empirically tested under agronomic conditions.
It examined the effect of the Leontief inverse on emissions changes into the specific effects of forward linkage, backward linkage, the average of forward/backward linkage and kernel structure.
The effect of linkage dynamics is included in the study.
Notably, ether-linked AMs exhibited significantly higher levels of inhibition of oxLDL uptake than their corresponding ester analogues, indicating a dominant effect of linkage flexibility on pharmacological activity.
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