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As a result, we were unable to dissect the effects of individual interventions (such has HAART for mothers versus co-trimoxazole for infants).
While there are studies evaluating the effects of individual interventions, less evidence exists on multimodal nonpharmacological approaches.
We adjusted the analysis for baseline scores and categorical variables of trial and treatment allocation, which adjusted for treatment effects of individual interventions.
The quantitative data we obtain may be better geared towards providing evidence of the overall impact of regeneration programmes rather than untangling the effects of individual interventions.
A fifth limitation concerns the assumption that the effects of individual interventions and their interactions will be similar for our countries, which may not be true as suggested by the differences observed between the overall set of countries and the African countries.
Similar(55)
Lack of studies testing intervention components Analysis of the effects of individual intervention components is needed in future studies.
The study was not designed to identify the magnitude of effect of individual interventions, and it remains therefore uncertain if the observed reduction in asthma is solely due to the reduction in tobacco smoke exposure or dietary alterations or a combination of both.
Both meta-analysis and meta-regression techniques were carried out in order to synthesise the individual trial data for each intervention and then examine the effect of individual intervention characteristics on each outcome.
The quality of evidence for the effects of the individual interventions on diarrhoea ranged from moderate (for ceramic filters and biosand filtration), to low (for distribution of chlorination kits, flocculation and disinfection sachets, and LifeStraw® filters), to very low (for water source improvements).
The effect of the combined rectal formulation was modelled by adding the treatment effects of both individual interventions.
A cluster randomized controlled trial with nursing homes as clusters is designed to verify the effects of 3 individual interventions: structured reminiscence therapy, 10-minutes activation and snoezelen.
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