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APOE genotype-specific risks of both tardive dyskinesia and Alzheimer's disease that vary across populations could be due to recruitment of patients or controls or could be due to modifying effects of differing genetic or environmental backgrounds.
To isolate the allelic effects of Hsp90 on quantitative trait variation independent of the effects of differing genetic backgrounds in mutant and control lines, we constructed highly isogenic Hsp90 mutant (P582i) and control (Sami) strains.
Given that at least 8 million SNPs exist in the mouse population [ 12], we decided to investigate the effects of differing genetic backgrounds and sex on alternative splicing patterns in a mammalian system.
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They come with varying degrees of acumen, training, experiences, differing genetic equipment, sensory capabilities, and of course, different preferences.
There is also data to show that biological agents including antitumour necrosis factor α and Interleukins 12/23 inhibitors are effective in the treatment of both psoriasis and PsA; yet, not all patients respond predictably, an effect potentially driven in part by differing genetic factors between the two conditions.
The often limited effect of differing temporal distribution of samples shows that opportunistically collected museum or archival specimens can be utilized effectively in genetic monitoring.
Differences in mapping results for genome-wide recombination number (or rate) in plants [ 8], humans [ 11], dairy cattle [ 10], and beef cattle suggest that genome-wide recombination could be regulated in a species-specific manner, that the effects of QTL differ between species, and that the genetic determinism of regulation of recombination is probably polygenic.
To identify metabolite and gene expression profiles that differed significantly for the effects of diet, genetic line, and the genetic-by-diet interaction, we used the linear model: Y i j m = μ + G i + D j + G × D i j + ε i j m for measurements taken from the mth individual sample in the ith genetic line (G) raised on the jth diet (D).
Estimates of the effects of QE3 differ.
The physiological effects of aging differ widely among individuals.
Thus, the effects of Cannabis differ by the potency and variety of Cannabis tested.
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