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Indeed, reduction of Kif3a in compound Pkd1+/Δ Kif3a+/Δ mice completely reversed the effects of deficiency of Pkd1 on bone mass and osteoblast and adipocyte differentiation, indicating deficiency of Kif3a rescues the bone effects of Pkd1 haploinsufficiency.
Since adipogenesis and osteogenesis are inversely related [65], [66], [67], the reduced adipogenesis in Kif3a haploinsufficient mice may have promoted osteoblasts differentiation to offset the effects of deficiency of Pkd1.
As Ang-(1 7) has been shown to have protective cardiovascular effects [21], [22] and this heptapeptide has been also described to have effects in the kidney [23], [24], we investigated effects of deficiency in the Mas receptor associated to Ang-(1 7) signaling in the UUO model.
Even though partial deficiency of Kif3a did not affect primary cilia number or formation, haploinsufficiency of Kif3a might disrupt IFT necessary for normal hedgehog signaling [18], [45], [51], [53], [54], [55], which in turn could counter the effects of deficiency of Pkd1 signaling [56], [57].
Few studies have investigated the effects of deficiency or excess of Mn on the human foetus.
Little is known about the effects of deficiency or excess of Mn on infant growth or birth outcome in humans [ 16].
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In the following, we study the effects of deficiencies in the uptake of neurotransmitters by the astrocytes both on extracellular concentrations and neural activity.
We examined the pleiotropic effects of deficiencies in SSI, BEI, and BEIIb on various protein fractions from developing endosperm.
Table 5 provides an overview of the current data regarding the effects of deficiencies or excesses of the micronutrients addressed in this review on genomic stability.
At the same time, the nutrients studied play a role in many different physiological processes, and potential health effects of deficiencies could arise through nonepigenetic mechanisms.
The effects of deficiencies in laryngeal sensory innervation to motor control and muscle integrity have been discussed by Nagai et al (2005).
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