The effect of a variation of the initial film thickness, the annealing temperature and time on the resulting grafted layers was investigated.
The addition of protein domains mapped to the amino acid sequences makes it possible to estimate any effect of a variation on protein structure and/or function.
The above Yeast 7.0 results, combined with literature support, sequence and pathway annotations, maintain our hypothesis that we should be able to use yeast orthologs with active site conservation to model the effect of a variation at the active site of its human ortholog in order to obtain a predictive overview of altered enzyme activity resulting from the variation.
Here, we generated a transgenic model, which carries the entire human genomic region of the SNCA gene, to study the effect of a variation located ∼10 kb upstream of the transcription start site within the putative promoter/enhancer region and to dissect its contribution to human SNCA expression levels in vivo.
To test the behaviour of the E-score metric we analysed the effect of A-score variation on E-score values for a chosen set of survey elements.
Furthermore, the effects of a genetic variation may be indirect where an ADR emerges secondary to the interaction of a variant protein and a ligand perturbed wild type protein.
The microstructural effects of a parametric variation of the parameters for fibre radii distribution are simulated, and the influence on the fibre architecture is investigated.
We apply this method to study the effects of a systematic variation of the poly-alanine repeat lengths, a parameter controlled by the genetic makeup of silk, on the resulting molecular structure of silk at the nanoscale.
To suppress the effects of a rapid variation of the noise power spectrum with frequency, we followed Godin et al. [21] and evaluated the noise cross-correlation as a Fourier transform of the coherence function, rather than the cross-spectrum.
During this period, the effect of T a variation is smoothed, and the average value of T a produces similar results as its variable values.
