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They are aimed to explore pharmacologic effects of a test molecule.
A common method to minimize the practice effects of a test is to use alternate forms.
Nonetheless, the rationale for decision curve analysis is to evaluate the clinical effects of a test, model or marker.
For example, liver weight, liver histopathology, and clinical indices of liver function are among those endpoints assessed to characterize the hepatic effects of a test substance.
Furthermore, any reduction in the inter-individual variability of growth and development will enable more sensitive assessment of the possible effects of a test compound on the development of tadpoles.
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The use of live bacterial reporters as sensing entities in whole-cell biosensors allows the investigation of the biological effects of a tested sample, as well as the bioavailability of its components.
We used this statistic as it more directly describes the effect of a test result (in this case GRG status) on the odds of disease [59].
This method provides a summary estimate of the average prognostic effect of a test.
Although researchers can follow standard epidemiological principles for intervention studies when designing studies to measure the effect of a test on patient management, the interpretation of this endpoint as a surrogate for health outcomes raises different unique issues.
In these cases, the effect of a test ligand on observable nuclei is directly monitored by collecting NMR spectra of the protein receptor in the absence and presence of various concentrations of ligand(s).
We chose to block the membrane enzymes, rather than PKs, because, as reported also by Hoey, chemical inhibitors of PKs are toxic for cells and mask the proliferative effect of a test factor.
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