Sentence examples for effects of a mutation from inspiring English sources
CHICAGO -- The experimental drug PLX4032, which reverses the effects of a mutation found in certain tumors, is considered a prime example of the "targeted" cancer therapies of the future.
In order to determine the effects of a mutation, measurement of physiological variables, such as biopotentials, is often necessary.
Thus, in many cases the impact of multiple mutations can be calculated by first determining the effects of a mutation at a single position and subsequently summing these effects using the quasi-additive assumption.
To test this, we analysed the effects of a mutation that disrupts the ability of Sgs1 to interact with Mlh1 (sgs1-mlh1-id) [64].
To assess the effects of a mutation of one of the above Ile residues on phosphorylation and clock rhythm we generated the I430A mutant.
Thus, it sometimes or even frequently shows pleiotropic effects; effects of a mutation differ depending on the affected gene.
The other, Zelboraf, from Roche and Daiichi Sankyo, blocks the effect of a mutation in a gene called BRAF.
In particular, the drug counters the effect of a mutation in a gene called B-RAF that was discovered in 2002 to be common in melanomas.
Epistasis is the dependency of the effect of a mutation on the genetic background in which it occurs.
Therefore, we developed a web server named the Kinase Resistance Docking System (KRDS) that allows researchers to easily evaluate the effect of a mutation on drug binding.
