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I particularly liked the overlay feature that offers some cool effects in the background.
But then it came out, and it was just a bunch of blue people running around with super expensive special effects in the background.
When considering only the relative alterations of the mid-activation potential Vm, the mid-inactivation potential Vh and the recovery time constant τf, mutation T1620K produced similar effects in the background of most splice variants (Fig. 7).
These alleles would not normally be removed by selection, as their effects in the background of the parent populations are neutral or positive.
This work is a good reminder for all geneticists to pay attention to the population effects in the background controls, and presumably the mutant lines we are comparing.
However, despite the disruptive phenotypes observed in homotetrameric Thr441Val or Thr442Val channels, single subunit mutations had minimal effects in the background of a concatenated tetramer.
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To investigate the role of AMPK in metformin-induced extended median lifespan in C. elegans, we tested for metformin effects in the backgrounds of two independent aak-2 alleles: aak-2 ok524), aak-2 ok524molecular null [55], and aak-2(rr48), which carries a presumedtation predicted to disrupt the catalytic activity of the α subunit [57].
By applying the pigment in a certain way, Michelangelo created an "unfocused" effect in the background and focused detail in the foreground.
M136I, which immediately preceded V280A in the natural evolution, mostly rescues its deleterious effect in the background of Aichi/1968.
Indeed, it is well known that mtDNA mutations increase with age, and recent findings show that this increment is likely due to errors in replication machinery or to unrepaired damage, placing ROS mutagenic effect in the background.
He wanted to make movies where the effects were in the background and the human condition was to the fore.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com