Non-differential misclassification is generally associated with an underestimation of effects and would rather have attenuated the real effect of enrolment on mortality.
Isoflurane is known to have a cardioprotective effect which may have attenuated the severity of the hypoxia challenge on these animals [21].
However, the metabolic effects of dexamethasone may have attenuated the benefits of STF.
For example, in a disome, even modest increases in the expression of some genes, such as transcription factors, present on the disomic chromosome, can have attenuated effects on transcription levels of related pathway genes found on other chromosomes (Rancati et al. 2008).
Therefore, increased exposure measurement error may have attenuated effect estimates for the association between PM10 oxidative burden and carotid intima-media thickness to a larger extent than those for PM10 mass concentration.
Finally, non-differential exposure misclassification, particularly for common conditions such as allergic rhinitis that do not generally have serious clinical implications or result in a hospitalisation may have attenuated our effect estimates.
This might have attenuated potential effects, although stratified analyses showed no sign of differential effects comparing active and sham filtration and we had reasonable statistical power to detect relevant effects in subjects not taking any drugs.
This might have attenuated the effects observed for the treatment with clonidine, which might have been even more pronounced if anaesthesia had been achieved using a different drug.
This raises the possibility that endothelial cells may have additional compensatory mechanisms, including redundancy in the function of other sirtuins, which could have attenuated the effects of the loss of SIRT6.
This limitation of the study might have attenuated the effects of obesity in outcomes other than macrosomia and CS because of the variation in maternal weight gain during pregnancy; however it would not produce false positive results.
