While not believed to have teratogenic effects, excessive caffeine intake may account for low birth weight in infants.
We hypothesized that, in line with all its reported adverse effects, excessive levels of C5a might greatly impair the adrenomedullary catecholamine production and/or their release during sepsis, which might result in septic shock.
The trial was interrupted by the ethics committee due to the adverse effects (excessive bleeding) observed in the placebo group during follow-up.
Because of its strong vasopressive effects, excessive vasoconstriction and a decrease in cardiac index are associated with bolus injection of terlipressin [ 3- 6].
Because of their potential harmful effects, excessive ROS must be promptly eliminated from the cells by a variety of antioxidant defence mechanisms, including important enzymes, such as superoxide dismutase (SOD), catalase, and various peroxidases.
On each visit a brief physical exam was performed, including measurement of weight, blood pressure, and pulse and the presence or absence of edema was recorded and graded at each visit, as was information for subjective assessment of medication side effects (excessive weight gain, edema, other).
