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It may be that all dissociated GR ligands with transrepressive effects equivalent to glucocorticoids will display some degree of undesirable effect on the HPA axis.
Tricyclic antidepressants, even at low doses, had analgesic effects equivalent to those of serotonin and noradrenalin reuptake inhibitors, but were less well tolerated.
In summary, shorter alkyl chained glycol ethers produced greater embryotoxicity than those having longer chains, and the ester produced effects equivalent to the ether, both patterns predictable from the biochemical literature.
In humans, lavender has been shown to lower plasma cortisol levels [ 7, 8]; reduce the need for post-operative analgesia [ 9], and exert anti-anxiety effects equivalent to those of lorazepam 0.5 mg daily [ 10].
We also note a further two, previously unreported loci, containing SNPs displaying evidence for association with TL: 6p22.1 containing the ZNF311 gene (lead SNP rs9257445, Ptrend = 1 × 10−7) and 20q11.2 containing BCL2L1 (lead SNP rs6060627, Ptrend = 6 × 10−7), with per-minor-allele effects equivalent to a 38 bp shorter TL and a 36 bp longer TL, respectively.
Because the A and T bases alternate within the poly(AT) block, the change of the intensity corresponding to a 1 base pair displacement of the block is, neglecting the end-of-the-block effects, equivalent to moving all A and T nucleotides to the opposite strands of dsDNA.
Similar(54)
Over the next century, selecting more reflective crops could have a cooling effect equivalent to preventing 195bn tonnes of CO2 from entering the atmosphere.
One round-trip flight from New York to Europe or to San Francisco creates a warming effect equivalent to 2 or 3 tons of carbon dioxide per person.
It has a warming effect equivalent to two or three tons of carbon dioxide per person, but does not generate that much carbon dioxide per person.
He then had to spend several days apologizing, but it's easy to see what he was trying to say: as President, he wanted to have a liberal effect equivalent to Reagan's conservative one.
More statistics: "Millau cut out five-hour traffic jams, which meant that the saving in CO2 from the 10% of traffic that is heavy good vehicles had an effect equivalent to a forest of 40,000 trees".
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