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Mr. Thomson observes that "the movies had always loved new special effects" — "Citizen Kane," for one, is full of them — but "in the years after about 1970, the ability of these effects, culminating in computer-generated images, to release violence was beyond question and out of control": "all too often, it was a 'fun ride' separated from pain, damage and consequence".
Observational studies of hypothalamic DBS (hBDS) seemed to report slightly better results, but also more serious side effects, culminating in fatal cerebral haemorrhage in one patient.
Multiple mechanisms of action possibly underlie the benefit of an iPS cell-based intervention, including putative differentiation into cardiomyocytes, vasculature and/or paracrine effects, culminating into induction of an innate regenerative response.
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Whereas these effects culminated into several-fold changes in total VEGF165 and sVEGFR1 in muscle tissues, the fractional occupancy of total matrix sites remained very low (at a consistent 0.19% irrespective of matrix site densities) and changing minutely with varying VEGF165-affinity (up to 0.55% at 10× control Kd(M,V165).
These effects culminate in growth restriction that may have multiple effects throughout the life of children.
These effects culminate in poor health and well-being among women depending on the thresholds of exposure in the mining communities compared to the less stressed communities.
All of these FGF21-mediated effects culminate in a reduction of blood glucose levels and maintenance of the non-diabetic state.
Collectively, these PGC-1α effects culminate in the regulation of mitochondrial biogenesis and energy metabolism (Lin et al., 2005; Rodgers et al., 2008).
Hence, the downstream elicited effects culminate in the control of cellular metabolic robustness, which in turn defines the threshold for cell viability.
That effect culminates at the top-floor library, where a long, narrow terrace extends out underneath the building's steel canopy.
Classes of trials with fewer discrepancies have found progressively smaller effect sizes, culminating in discrepancy-free trials reporting an effect size of zero Cite this as: BMJ 2014 348 g2688.
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