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While comparisons of C99WT, C99I45F and C99V50F with mock-transfected cells provided information about C99-overexpression effects, comparisons of C99I45F and C99V50F with C99WT provided information about Aβ effects (Table 1).
In the analysis of simple main effects, comparisons among groups at a specific time point were performed.
For response rates and the presence of toxic effects, comparisons of the two treatment arms were done by the χ test or the Fisher's exact test, when appropriate.
To eliminate DNAm differences that can arise due to genetic effects, comparisons were made between cell types derived from the same set of individuals.
When the overall model indicated significance, we conducted post hoc pair-wise comparisons with Tukey's HSD (honest significant difference) test for main effects comparisons (Siegel 1956; Steele and Torrie 1980).
Although comparisons between the concurrent control group and the exposure groups are the most valid for identifying chemical-induced effects, comparisons with historical control data may also be helpful in interpreting treatment-related effects (Haseman et al. 1984).
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Figure 4 Control effects comparison estimated by average stops.
Figure 6 Control effects comparison estimated by maximum queue length.
Figure 5 Control effects comparison estimated by average waiting time.
Once toxicity testing indicates approximate doses associated with biological effects, comparison with biomonitoring data can help focus on exposures of greatest concern.
Effect comparisons among the different polyacrylamide hydrogels were made and the mechanism of silica improving polyacrylamide hydrogel with high mechanical properties was proposed.
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