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The new methodology is especially interesting to be applied in minimal screening designs, for which other error estimates (e.g. based on interaction or dummy effects) cannot be applied.
In the most recent NHANES DLC data, 2005 2006 and 2007 2008, participants' sera have been physically pooled prior to laboratory analysis, introducing major challenges to their utility as a reference population: variability among individuals and relations with covariates are lost, and individual design effects cannot be applied.
Note that once interaction terms (or other nonlinearities) are included in the SEM, the simple method of multiplying path coefficients to calculate path-specific effects cannot be applied (VanderWeele and Vansteelandt, 2009).
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The global model with fixed effects (GMFE) cannot be applied to data with a large number of gene expression probes (number of genes greater than number of subjects), due to the model being non-estimable.
2 Its counterpart, the random effects model, cannot be applied because of the structure of spatial data.
Moreover, the effective dose cannot be applied for therapy with radiopharmaceuticals as it only considers the stochastic effects.
Therefore, side effect-based methods cannot be applied to new drug candidate compounds (e.g., newly synthesized compounds) that are yet to have their side effects profiled.
CA has an important limitation in that it cannot be applied to effect levels greater than the maximal effect achieved by the least efficacious compound included in the mixture (Silva et al. 2002).
This crack branching mechanism can quantitatively explain retardation effects even when plasticity induced crack closure cannot be applied, e.g. in high R-ratio or in some plane strain controlled fatigue crack growth problems.
The main lemmas in [21, 24, 29] cannot be applied in the present study because of the effects of impulses and infinite delays.
Furthermore, in this case the buffer-based time-multiplexed scheme described in the previous Section cannot be applied, since each channel coefficient cannot share its Doppler filtering stage (the Doppler effect parameters differ greatly from one coefficient to another).
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