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Specific unwanted types of drug effects can be specifically studied using detailed neuropsychological test batteries.
Based on our present results, three major biological effects can be specifically attributed to the knockdown of ROCK2: inhibition of apoptosis, attenuation of axonal degeneration and promotion of neurite outgrowth.
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Our current data demonstrate that E2 can exert profibrotic activity ex vivo in human skin and that this effect can be specifically blocked by ICI 182,780.
Baldwin et al. [ 1] reviewed biomarker research for the commercially most important mycotoxins and defined biomarkers as measurable biochemical or molecular indicators of either exposure (exposure biomarker) or biological response (effect biomarker) to a mycotoxin that can be specifically linked to the proximate cause.
Even if SERCA can be specifically targeted, such inhibition does not effect on T-ALL cells with activated Myc mutations or lacking NRR region [ 37].
And because they seem vital "these genes can be specifically monitored during drug development for potential side effects and cytotoxicity," Xu says.
Furthermore, via examination of the effect of the D2-K317R mutheinteractionteractiof of the NO3– bound to the Cl-1 site can be specifically studied.
Where effects can be attributed specifically to removal (e.g. increased NO3-N), there may be potential to mitigate effects through different removal strategies.
Again, the close packing of structures in the vicinity of RA, and the difficulty of defining the borders of chemical lesions, raises concerns over the degree to which the observed effects can be attributed specifically to lesions of the anatomically defined AIV. 5) Effects of lesions on amount of singing.
To corroborate these findings, we utilized an RNAi strain wherein the effects can be localized specifically to dopaminergic neurons expressing α-synuclein and reduced the sole E1 activating enzyme uba-1 and six diverse 26S proteasome regulatory subunits (psmd-9, rpn-2, rpt-1, rpt-4, pas-3, and pbs-3) in this strain.
Because the effect concentrations of human or synthetic hormones are often below the limits of quantitation (LOQs) of analytical methods, these substances are analytically difficult to monitor but their effects can be measured with specifically designed assays [12].
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