21 Although a number of studies have demonstrated short-and long-term efficacy of oxybutynin in the treatment of primary HH, the anticholinergic side effects and requirement for chronic pharmacologic therapy limit the use of this medication for some patients.
(Nitroglycerin tolerance is manifested as a reduced vasodilatation effect and requirement of high doses of the drug after continuous treatment).
One of the main drivers for understanding krill biology has been the fisheries' requirements for stock forecasting and conservation measures, but this is now joined by concerns over climate change effects and the requirement to take a more holistic over-view to understand food web structures [7], [24], [25].
However, due to the laser induced heating effects and the requirement of a reference Raman spectrum in Raman spectroscopy measurements, contrast spectroscopy is non-destructive and more efficient.
The third variation arose from clinical trial analysis of heart rate and blood pressure data which has culminated in strengthened wording relating to cardiovascular effects and the requirement to conduct baseline and ongoing monitoring of pulse and blood pressure and contraindications for patients with severe cardiovascular and cerebrovascular disorders as is the case for methylphenidate.
Patient satisfaction with anesthesia, the ability to resume normal activities on the first postoperative day, adverse side effects, and the requirement for postoperative analgesic and antiemetic drugs were recorded in the early postoperative period and during the initial 24-h period after discharge.
The current drugs to treat HAT are inadequate, due to poor efficacy, side effects and the requirement for parenteral administration, which is not appropriate for a rural African setting. 2 Folate metabolism has been successfully used as a drug target in a number of diseases such as cancer, bacterial infections and malaria.
The current drugs to treat HAT are inadequate due to poor efficacy, side effects and the requirement for parenteral administration, which is not appropriate for a rural African setting. 1, 2 Herein we report a target-based approach to the discovery of novel inhibitors of trypanothione reductase (TryR) as a potential therapy for HAT.
Elvitegravir has demonstrated good efficacy and safety, with minimal side effects and no specific requirements in terms of laboratory monitoring.
32 Elvitegravir has demonstrated good efficacy and safety, with minimal side effects and no specific requirements in terms of laboratory monitoring.
