The central meeting themes were "Annotation and prediction of structural/functional impacts of coding variants" and "Genetic variants as effectors of change: disease and evolution".
Collagen induced arthritis and injection of anti-collagen antibodies represent the priming and effector phases of disease, respectively.
Expression of IFNα/β in the effector phase of disease instead was suggested to mediate protective effects by acting directly on myeloid cells [ 3].
In this report, we show that in the K/BxN murine model of arthritis, which emulates the effector phase of disease, PAD4 activity and NET formation are detected.
Our results suggest that PAD4 activity and subsequent NET formation is present in the K/BxN serum transfer model, but is not required for this model of effector phase of disease.
Autoreactive CD8+ T cells induce β-cell destruction upon activation via MHC class I engagement on β cells during the effector stage of disease and are essential in priming and expanding diabetogenic CD4+ T cells.
Targeting specific molecular or effectors of different diseases have shown therapeutic advantages and great potential as an important aspect of precision medicine.
PAD4 WT and KO mice develop disease in the K/BxN serum transfer model of arthritis with similar severity and kinetics, indicating that PAD4 is dispensable in this effector phase model of disease.
Specific recognition of pathogen effectors leads to the induction of disease resistance and HR.
Allogeneic NK cells are not direct effectors of graft-versus-host disease but this may occur if donor NK cells are infused after allogeneic hematopoietic stem cell transplant, which may activate T cell alloreactivity.
