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Allosteric effectors may be formed by enzyme-catalyzed reactions in the same pathway in which the enzyme regulated by the effectors functions.
These phage-encoded effectors may be principle subjects of contemporary selective processes shaping Salmonella-host interactions.
Thus, hierarchical injection of TTSS effectors may be a common principle governing the early phases of these bacteria-host interactions.
Such specificity and commonality in GEFs and effectors may be reflected in the slightly different temporal localizations between the two Rab proteins.
Or, the accumulation of these effectors may be a result of the challenges faced by the bacterium to colonize phylogenetically diverse amoebae host in its natural niches.
These results together suggest that inhibition of the pathway activity both at the level of the receptor, and its downstream effectors may be required for an effective anti-cancer therapy.
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In this context, such non-microbial bio-effectors may be particularly effective under conditions where PGPM activity is inhibited by unfavorable environmental conditions.
While the incremental contribution to virulence of a single additional RXLR effector may be difficult to measure against a background expression of hundreds of these genes, natural selection provides a powerful force that shapes genomes on the subtlest of traits.
In certain circumstances the end effector may be the elbow or the point of a tool held in the hand (Tanaka et al. 1996).
XBP1 is always overexpressed in advanced plaques, a finding that may reflect a proatherogenic role of long-term XBP1 upregulation whereas limited stimulation of this ER stress effector may be protective against ER stress [ 61].
Drawing on our study on marriage migration we demonstrated the value of our model, ensuring as it does that a study does not fall into the trap of investigating experiences in one domain of integration without regard to the impact in others, or fail to recognise the full range of effectors which may be at play.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com