Exact(23)
An increasing number of effectors has been characterized for Oomycetes28.
The interaction of the GTP-bound Ras (RasGTP) with its effectors has been studied intensively.
Until now, functional analysis of Meloidogyne spp. effectors has been essentially limited to M. incognita and to a lower extent to M. javanica, having A. thaliana or tomato as host plants.
A basis for the regulation of threonine deaminase by heterotropic effectors has been studied by capitalizing on the intrinsic fluorescence of the essential pyridoxal phosphate cofactor in this enzyme in kinetic and equilibrium binding studies with the substrate analog D-threonine.
However, the secretion of Phytophthora cytoplasmic effectors has been documented only in haustoria to date.
Owing to this nodal role, enhanced traffic through RAS proteins and their downstream effectors has been established to have a major impact on oncogenesis (3, 4).
Similar(37)
A number of Xcv TTSS effectors have been identified; however, their function in planta remains elusive.
RAS and its downstream effectors have been targeted to develop therapeutic inhibitors in various cancers with frequently mutated KRAS or BRAF54,55,56.
RNA Interference (RNAi) effectors have been used to inhibit rogue RNAs in mammalian cells.
More than 60 putative EHEC type III effectors have been proposed using the proteomic approach [39] and bioinformatic studies [40].
Small GTPases and their downstream effectors have been implicated in steroid action in vitro and in vivo [4], [5], [14], [15], [29], [30], [37].
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