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First discovered as intracellular effectors for the Robo1 axon-guidance receptor, srGAPs were later identified as interacting with several other nuclear and cytoplasmic proteins.
Moreover, new network technologies like Low Power Wide Area (LPWAN) or 3GPP protocols and the appearance on the market easily programmable nodes allow to create, at low-cost, sensors and effectors for the Internet of Things.
In vitro and in vivo evidence proved that long-chain fatty acid (LCFA) acyl-CoA thioesters are small molecule effectors for the FadR regulatory system (Henry & Cronan, 1992, van Aalten et al., 2001, Cronan, 1997).
Cells (15×103 cells/100 µl) were incubated with the effectors for the times indicated.
Then, these evidences suggest that mutations behave as effectors for the definition of possible interactions sites.
Monk, [17] further supports this notion while also indicating the need to further elucidate the effectors for the transcriptional delay in negative feedback oscillatory systems.
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There was a slight amount of cross talk between small molecule effectors; for example, the synCRP reporter showed slight inhibition as the concentration of arabinose increased.
Evidence in transcriptome level was used to evaluate the TGFβ1/BMP4 combination as a previously unexplored effector for the smooth muscle differentiation of adipose stem cells.
Therefore, these kinds of manipulators are usually taken as the end effector for the micro-nanorobot.
Calmodulin (CaM) is a major effector for the intracellular actions of Ca2+ in nearly all cell types.
As shown in Figure 8, in the reachable workspace (illustrated with red curve), ETI values are relatively large, which indicates that the transmissibility of the end effector for the 5R mechanism is quite good.
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