Sentence examples for effectors for example from inspiring English sources

During the process of immune evasion, tumour cells can develop resistance to immune effectors, for example, interferon γ (IFNγ 31.

Some of the hit genes have previously been found to be effectors, for example MET for L. monocytogenes.

There was a slight amount of cross talk between small molecule effectors; for example, the synCRP reporter showed slight inhibition as the concentration of arabinose increased.

We describe an increased rate of mutations in receptor tyrosine kinases (RTKs) and associated signaling effectors, for example, in EGFR, ERBB3, KRAS and MAP2K2, pointing to a role of aberrant RTK signaling in the development or progression of MM.

PKA activity is essential to prevent the expression of Hedgehog effectors, for example Gli, albeit no mutation was up to now detected in PKA genes R1A, R1B, R2B, CA and CB [ 19].

Recent localization studies have shown that Ras, Ira, and Cdc25 as well as some of their downstream effectors, for example the AC, Cyr1, are not only localized at the plasma membrane but also associated with internal membranes, in compartments such as the ER, mitochondria, and nucleus (Belotti et al., 2011, 2012; Dong & Bai, 2011; Broggi et al., 2013).

In previous structures of Rab GTPases in complex with their effectors, the CDR/RabSF3 has been found to be in contact with the effector, for example the Rab3a Rabphilin structure (Ostermeier & Brunger, 1999).

The ability to detect phenotypes also depends on the strength of the effector; for example, four glutamatergic MBON drivers showed aversive memory impairment in initial screening assays with a strong inhibitor of synaptic function, but we were not able to confirm these effects using a weaker effector.

Similarly, Nck would recruit other actin downstream effectors as for example N-WASP to the site of integrin delivery and activation.

Immune signals are sharing a common signaling pathway and propagate to amplify effectors cells; for example, TLR signals are propagated to tumor necrosis factor (TNF) receptor associated factor-6 for activation of NF-kB and mitogen activated protein kinases [ 49].

For cases where mAbs are intended to engage cell surface receptors and prevent receptor-ligand interactions (i.e., antagonists), it may be desirable to reduce or eliminate effector function for example to prevent target cell death or unwanted cytokine secretion.