Blocking TRPC3, the effector channel of a cascade of proteins that have zebrin-like distribution patterns, attenuated the simple spike frequency difference.
Additionally, mGluR6 and its effector channel TRPM1 are further integrated by a scaffolding protein, nyctalopin (Cao et al., 2011; Pearring et al., 2011).
We targeted EAAT4 that is expressed in a pattern similar to that of zebrin, and TRPC3, the effector channel of a cascade of proteins that has zebrin-like expression patterns (Dehnes et al., 1998; Mateos et al., 2001; Wadiche and Jahr, 2005).
We hypothesized that differential activity of this cascade of proteins with zebrin-related expression might lead to differential activity of their effector channel, TRPC3, and thereby to differences in simple spike (SS) firing frequency between modules (Kim et al., 2012a, 2012b).
The authors are aware of only one study that functionally and structurally characterized a tick Kunitz peptide as an ion channel effector, the maxiK channel modulator Ra-KLP from R. appendiculatus[ 40].
Receptor density plays a large role in defining the response of downstream effectors (IKs channels in this case) and differences in density can lead to significant shifts in EC50 curves.
KCTD12 induces GABAB receptor-activated K+ current desensitization by binding to the βγ subunits of the activated G-protein, which interferes with activation of the effector K+ channel [ 19].
Intermolecular interaction force maps can be used to define specific domains of an effector (e.g., channels and receptors).
The type III secretion system (TTSS) provides bacterial pathogens, with a structure that channels effector proteins into the cytoplasm of eukaryotic host cells (Tampakaki et al, 2004).
Gβγ subunits can regulate a diverse array of effectors, including ion channels and enzymes.
