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Initial effectiveness, estimated using two different methodologies was 80%95%5% CI-: 52.5 91.6%) for children 6 mo to less than 5 y of age and 73%95%5% CI-: 52 85%) for all ages.,,, However, since this was a large-scale introduction rather than a clinical placebo-controlled trial, interpretation of effectiveness was complicated by secular disease trends.
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Treatment effectiveness is complicated by the presence of reactive stroma, which is associated with tumor invasiveness and drug resistance [ 8– 11].
Assessment of effectiveness is complicated by the degree of match between vaccine and virus, which varies from year to year with mismatches leading to lower vaccine efficacy (4, 5).
18 The medical literature regarding their effectiveness is complicated by the heterogeneous nature of these treatment modalities and the patient population, with pooled analyses and systematic reviews demonstrating, at best, a modest benefit.
In the Finnish setting, the interpretation of cost-effectiveness is complicated by the fact that the WTP threshold used for decision making has not been publicly announced.
"It was complicated, very complicated.
The plan was complicated.
It was complicated.
Estimation of influenza vaccine effectiveness (VE) is complicated by various degrees of mismatch between circulating and vaccine strains each season.
However, these future effects could be complicated by increasing levels of atmospheric CO2, varying effectiveness of legally protected areas and shifting consumption patterns.
Although these agents have demonstrated potent antiviral effectiveness, monotherapy has been complicated by rapid virological breakthrough due to the selection of drug-resistant mutants.
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CEO of Professional Science Editing for Scientists @ prosciediting.com