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The effectiveness of these trials varied with regard to the success of changing the behaviour of the clinicians [ 26].
Combining cognitive testing paradigms with physical biomarkers such as functional imaging and electroencephalography may provide greater insight into underlying disease mechanisms and increase the potential effectiveness of these trials.
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The proven effectiveness of these two trials has given urgency to the question of whether such effects might be replicated in community settings, including primary care.
Disadvantages of retrospective recruitment include weaker control of bias or other unknown factors influencing the effectiveness of the trial.
Further, to reimburse MNHG members would have reduced the opportunities to evaluate the effectiveness of the trial.
Herein, we describe major problems in the interpretation of the primary measure of effectiveness proposed for these trials, namely the ratio of HIV incidence in the experimental agent group to that in the active-control group.
We agree that it may be wise to investigate whether setting affects effectiveness before combining all of these trials, but we do not agree with the method by which Moore et al undertakes this investigation, nor their implication that the methodological problem could only occur if one pools trials inappropriately.
The key change is the creation of a new health research regulatory agency, known as the National Institute for Health Research NIHRR), to streamline regulation and improve the cost effectiveness of clinical trials.
A meta-analysis aggregates indexes of effectiveness of individual trials into one pooled estimate.
To conclude, evidence regarding the effectiveness of universal trials is inconsistent.
A narrative review of the effectiveness of 36 trials found only 11 trials to be successful in reducing PS exposure in children [ 10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com