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The method assumes that LNC proliferative responses are causally and quantitatively associated with the effectiveness of sensitization induction (ECETOC, 2003, 2008), yielding results that quantitatively describe relative sensitizing potency, which correlates with human sensitization thresholds (Loveless et al., 2010; van Loveren et al., 2008).
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The effect of prior sensitization or responsiveness to mycobacterial antigens for the effectiveness and outcome of subsequent immunotherapy with BCG is still a matter of intensive debate [ 21- 23].
These inefficiencies had implications for program cost-effectiveness by limiting beneficiary time spent in vegetable production, training sessions and other forms of sensitization.
Degree of sensitization.
The mechanism of sensitization and activation is established.
Recently, skin sensitization has been formulated as an adverse outcome pathway (AOP) to address the complex nature of sensitization [19].
We explicitly state that reduced PPTs 'reflect signs of sensitization' and 'are supposed to reflect signs of sensitization'.
Over the past decades evidence has emerged of the involvement of sensitization of central nervous system nociceptive pathways (i.e. central sensitization) in several chronic pain disorders.
This was considered Day 1 of sensitization.
This form of sensitization is related to changes in the properties of primary nociceptive afferents (peripheral sensitization), whereas central sensitization requires functional changes in the CNS (neuroplasticity).
This form of sensitization has been variously referred to as "conventional" or "nociceptive" sensitization [ 39] or "extrinsic" sensitization [ 10, 27, 37, 42, 48, 49].
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