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The administration of cisplatin is associated with serious side effects, such as nephrotoxic and neurotoxic events [ 9], and the effectiveness of radiation therapy is limited by damage to the normal tissue.
The advisory committee said Allos had not proven that RSR13 improved the effectiveness of radiation treatments.
The trials were actually begun to see whether the drugs improve cancer survival, on the theory that delivering more oxygen to tumors can improve the effectiveness of radiation therapy or chemotherapy.
He said the finding that the drug did not seem to improve the effectiveness of radiation in people with head and neck cancer was reasonable, though it needed more study.
Currently, however, no study has been able to demonstrate the effectiveness of radiation even in ASC of the esophagogastric junction most likely due to the rarity of the disease.
Tumour-cell hypoxia, a common feature of solid tumours, is a pivotal determinant of the effectiveness of radiation, chemical, and immune therapies and is associated with poor overall survival [2, 3].
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Targeted radionuclide therapy combines "the favourable targeting properties of peptides and antibodies with the effectiveness of radiation-induced cell death.
Targeted radionuclide therapy combines "the favorable targeting properties of peptides and antibodies with the effectiveness of radiation-induced cell death.
Knowledge about the single-event energy deposition in a subcellular biological target, e.g. cell nucleus, is required in order to understand the radiation action and the biological effectiveness of ionizing radiation.
The effectiveness of hyperfractionated radiation therapy, i.e., irradiation over optimal intervals, targeting the most sensitive stages of the tumour cell cycle, has also been investigated.
Biological effectiveness of ionizing radiation differs with its linear energy transfer (LET) such that high-LET radiation is more effective for various biological endpoints than low-LET radiation.
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