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The strengths of the IDEAL Project lie in its pragmatic nature [ 43, 44], which is expected to enhance external validity and inform understanding of effectiveness, implementation, and cost-effectiveness to inform future development and adaptation.
Questions related to pirenoxine and glutathione eye drops included: frequency of prescription, perceptions about effectiveness, explanations to patients about their effectiveness, implementation of the related clinical guideline (see Appendix), and how the guidelines influenced their practices.
We have used this evidence as the basis of a comprehensive rapid evidence synthesis relating to the effectiveness, cost effectiveness, implementation, delivery and impact of enhanced recovery programmes with particular reference to secondary care hospital settings in the NHS (Paton et al, in preparation).
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Moreover, they demonstrate how the Proctor et al. (2011) framework can be operationalized and applied specifically to hybrid effectiveness-implementation design studies.
Talking Health, a type 1 effectiveness-implementation hybrid trial targeting adults in rural southwest Virginia, was developed using the RE-AIM planning and evaluation framework (reach, effectiveness, adoption, implementation, maintenance).
A pragmatic cluster-randomised controlled trial within a hybrid effectiveness-implementation study design.
This mixed-methods study uses a hybrid effectiveness-implementation design in a single center randomized controlled trial (RCT).
SMS was evaluated by means of a type 2 hybrid effectiveness-implementation study design, in which the regional implementation strategies and the effectiveness of SMS were evaluated simultaneously.
Using a hybrid effectiveness-implementation design, the project relies heavily on the RE-AIM evaluation framework (Reach, Effectiveness, Adoption, Implementation, Maintenance) [ 22, 23] (see Figure 1).
This ongoing blended effectiveness-implementation design holds the potential to advance the science and practice of caring for complex medically ill patients within the constraints of a busy patient-centered medical home.
This simultaneous focus on effectiveness and implementation outcomes, defined by Curran et al. [ 21] as a hybrid effectiveness-implementation trial, is intended to reduce the translation lag from intervention development to intervention implementation and adoption in routine practice.
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