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Our simplified model uses only the simulated drug-related costs, ignoring both the non-drug-related cost and the effectiveness components of the ICER, because the future introduction of generic dabigatran etexilate would only affect the drug- related costing component of the ICER (see Equations 7 and 8).
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The economic component of the review was restricted to economic analyses conducted alongside the studies meeting eligibility criteria for the effectiveness component of the review.
The cost effectiveness component of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) found that average monthly healthcare costs were $US300 $US500 greater with the newer second-generation medications than with perphenazine, with no significant advantage in symptom control or quality of life (Rosenheck et al. 2006).
The EQ-5D was chosen as the quality of life measure rather than a disease specific measure such as the IBS quality of life measure (IBS-QOL) [ 35] because the EQ-5D was required for the cost effectiveness component of this study.
We describe the design of the cost-effectiveness component of the first large, randomized, placebo-controlled trial of lipid-lowering therapy in subjects aged 70 years or older.
The cost-effectiveness component of the 18-month CATIE trial of schizophrenia pharmacotherapy (n = 1460) showed that the first-generation antipsychotic perphenazine was US$300-600300-600nth less expensive than each of four second-generation antipsychotics, and no less effective across multiple measures.
The primary outcome for the cost-effectiveness component of the study will be EQ-5D [ 27].
One important aspect of the design of the cost effectiveness component of RCTs including those evaluating pharmacist interventions for pain relates to the selection of the most appropriate health utility measures.
The proposed cost-effectiveness component of this study will resolve this issue.
The results should therefore not be seen as due to the success of the TSU alone, but rather as progress for the state as a whole, using an innovative management model designed to enhance the effectiveness of components of the national government's plan.
Different pricing scenarios will also be tested to determine threshold values for achieving cost-effectiveness, including cost-effectiveness of different components of the strategy.
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