Sentence examples for effectively sensitized from inspiring English sources

We observed that TNFα or IFN-γ alone exhibits minimal sensitization effects, but effectively sensitized metastatic colon carcinoma cells to TRAIL-induced apoptosis when used in combination.

Moreover, it is worth mentioning that this nanocomposite could be effectively sensitized by visible light (λ > 385 nm), thus to reduce the effect of UV damage on living biological samples [15], making it of great potential in multi-modal biomedical imaging and diagnostic applications.

Our results indicate that T-cells can be effectively sensitized by in vitro methods and used as cellular probes to identify and differentiate glioma from radiation necrosis.

To extend the above findings that specific shRNAs against RELA and STAT5B effectively sensitized chemoresistant ovarian cancer cells to carboplatin killing, we sought to determine the effect of their small molecule inhibitors as potential chemosensitizers.

Each rabbit was effectively sensitized with heat-killed M. bovis and all converted their tuberculin skin tests to positive prior to infection similarly to previous work (Table 1) (18).

We demonstrated here that combined treatment of TNFα and IFN-γ, two physiologic cytokines of the host immune system, effectively sensitized metastatic human colon carcinoma cells to TRAIL-induced apoptosis (Fig. 1).

Recently, accumulating lines of evidence suggest that, through its lysosomotrophic effect, CQ can effectively sensitize cancer cells to the cell-killing effects of ionizing radiation and chemotherapeutic agents and, therefore, its use as an effective sensitizer for the improvement of the effect of conventional cancer therapies is a promising new therapeutic strategy [ 12].

Accumulating lines of evidence suggest that CQ can effectively sensitize cells to the effects of conventional cancer therapies (e.g., ionizing radiation and chemotherapeutic agents) in a cancer-specific manner, enhancing the treatment efficacy [ 47].

As a result, there is an unmet need to develop and optimize a therapy that would effectively sensitize cancer cells to radiation and avoid systemic effects on normal tissues, while allowing the use of a relatively low radiation dose.

In the present investigation, low concentrations of ouabain and the induced hybrid cell death mechanism effectively sensitize drug-resistant glioblastoma cells to the anti-cancer effect of TMZ.

Although LCL85 does not effectively sensitize Colon 26 cells to FasL-induced apoptosis, LCL85 is effective in suppressing Colon 26 cell metastatic potential in vivo, suggesting that other host factors, such as IFN-γ and TNFα secreted by T cells, might also act to sensitize the tumor cells to apoptosis in vivo, which requires further study.