Importantly, similarities between their trajectories indicate that age-related metabolites effectively recapitulate gradual and continuous aging transitions.
These models effectively recapitulate the time-dependent and multi-stage progression of cancer formation in response to relevant environmental carcinogens and tumour-promoting agents [ 22].
We have established an all-human hepatic microenvironment that can effectively recapitulate human breast cancer cell dormancy even through 15 days of culture.
In theory, easily accessible cell types (such as skin fibroblasts) could be obtained from a patient and reprogrammed, effectively recapitulating the patients' disease in a culture system.
This indicates that the pre-clinical model of induction therapy that we have developed in this study can effectively recapitulate the development of clinical drug resistance.
Collectively, these results demonstrate that trans-hENs effectively recapitulate the findings previously reported for Group 3 and 4 MB lines on cell growth.
Pre-clinical models that effectively recapitulate human disease are critical for expanding our knowledge of cancer biology and drug resistance mechanisms.
Despite their short length (∼20 40 amino acids), CMPs effectively recapitulate many features of their much larger (over 1000 amino acids long) natural counterparts.
Our initial observations showed that global metabolite profiling effectively recapitulated distinct stages of the aging process and revealed metabolites that strongly correlate with organismal survivorship.
Indeed, when cancer cells are grown as three-dimensional (3D) spheroids, they acquire multicellular resistance that mimics the chemoresistance observed in vivo and can effectively recapitulate some of the complexity of solid tumors.
