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These data demonstrate that the non-immunogenic, ES2 (in terms of eliciting 2F5 epitope-specific responses), is capable of effectively driving 2F5 epitope-specific memory B cell responses if effectively primed.
All of the tested tumor cell lines effectively primed human PBMC and/or differentiated MΦ.
Note that T cells from proteoglycan-immunized CD28-deficient mice proliferate in response to proteoglycan stimulation, albeit at a rate lower than that in wild-type T cells (Fig. 4c), suggesting that CD28-deficient T cells can be effectively primed.
This together with increased delivery of lysate antigens to compartments where efficient cross-presentation can take place, may explain why T cells, which have interacted with VLP-lysate pulsed DC and matured with an adjuvant, are more effectively primed for cytotoxicity.
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Colin Powell's flirtation with a presidential run was a critical point in this shift in white attitude, effectively priming the nation for the possibility of a black candidate.
Proteolytic modification of the MSP1/6/7 complex by PfSUB1 may represent an analogous process, functionally activating important merozoite surface molecules and so effectively priming the parasite for invasion.
The inauguration saw Ghani confirmed as president and Abdullah as chief executive, effectively prime minister in a post that has no status in the Afghan constitution.
During their short life span, monocytes can differentiate to become either macrophages [3] with prolific degradative capacity [4] or dendritic cells (DCs), which effectively prime T cells by presenting antigens [5].
It is therefore reasonable to assume that the perception of stress-related chemosignals does not activate emotion and empathy specific neuronal networks, but only less specific structures which effectively prime non-specific autonomic adjustments.
It is well accepted that tumor-specific CD4+ T cells essentially sustain the anti-tumor activity of CTL by licensing dendritic cells (DC) to effectively prime CTL [17], [18] or by maintaining profound CTL memory [19], as well as by direct stimulation of CTL [20].
This microsignaling may effectively prime proximal cells for the toxic microenvironment, allowing more cells to sustain viability despite environmental nutritional depletion and acidification.
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