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It may be that to treat CNS disease more effectively, peripheral ERT may have to be combined with other approaches, such as cell-based therapies, perhaps involving gene enhancement or replacement.
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In our study, the combination of sumatriptan and naproxen effectively altered peripheral activation of central pathways during early period and development of central sensitization during later periods.
Given that the TransMilenio network does not cover effectively the peripheral areas, the fare change mainly affects the low-income users of the public transport system.
The results show that strong arguments influence a green (environmentally concerned) population with many contacts most effectively, while peripheral cues have the greatest impact on a non-green population with fewer contacts.
It was argued that differences in the decision-making process between referees are possibly due to the ability to extract better quality information per fixation and the ability to acquire information more effectively via peripheral vision (Catteeuw et al., 2009; Hancock & Ste-Marie, 2013).
The postnatal rise in PaO2 effectively silences peripheral chemoreceptors, resulting in delayed onset of spontaneous breathing, especially when neonates are exposed to 100% oxygen during postnatal resuscitation [ 94].
These concepts will eventually also apply to the use of benralizumab, an IgG1 monoclonal antibody directed to IL-5 receptor, that in preliminary investigations has been reported to be quite safe and to effectively reduce peripheral blood eosinophils [ 68].
In our study, we found that prednisolone effectively suppressed peripheral CD16 levels in women with a successful pregnancy until 20 weeks gestation; however, this suppressive effect was not found in the levels of CD56 cells.
On the contrary, pulsed mode US therapy effectively enhanced peripheral nerve regeneration in an animal study, possibly through the mechanisms of local blood vessel dilatation, nerve sprouting stimulation, Schwann cell activation and chemotactic stimulator release [ 27].
In vitro flow cytometry analysis of chemotaxis-related receptors and in vivo cell trafficking assay further showed that DCs treated with [BF/S+L/Ep] were able to migrate more effectively to peripheral lymph node and spleen tissues than DCs treated as control groups.
Limiting feeding to the daytime in nocturnal animals effectively uncouples peripheral activity from what is dictated by the central clock and results in food anticipatory activity (FAA), which includes increased locomotor activity before the presentation of food as well as increased body temperature.
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