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For her best friend, the incident effectively marked an abrupt end to her childhood.
That moment effectively marked the end of Donald Sterling, the Worst Owner in Sports.
Indeed, it is so significant that this year the 60th anniversary of the liberation was effectively marked twice.
So Mr. Schundler's campaign effectively marked the end of the political careers of these two Republican stalwarts, and their friends and allies have neither forgiven nor forgotten.
But Lawson's resignation in October 1989 - followed almost immediately afterwards by Sir Alan's own departure - effectively marked the beginning of the end of Thatcher's premiership, which occurred just over a year later.
Bent made little impression during yesterday's 1-1 drawithth Newcastle as he was effectively marked by Fabricio Coloccini and Mike Williamson and it was strike partner Asamoah Gyan, who replaced him as the club's record signing when he made his £13million-plus switch to Wearside in August last year, who snatched a draw with a fortuitous equaliser.
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In any case, 1903 effectively marks the end of Frege's productive life.
The Petrobas report effectively marks the start of the production phase, and was filed twelve months before the deadline.
His death in 1744, seven years after Stradivari's, effectively marks the end of classical Cremonese violin-making.
It also effectively marks the start of next season, with the losing teams focusing their minds on where they went gone wrong this time.
One source said that if the cuts go through as proposed by management they will also effectively mark "the end of Scottish editions" of the Express Newspapers titles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com