Sentence examples for effectively downregulated from inspiring English sources

Psoralidin, a natural compound found in the seeds of the Asian medicinal plant Psoralea corylifolia, effectively downregulated NOTCH1 signaling, which resulted in the downregulation of EMT and growth arrest in BCSCs.

Consistently, overexpression of RHOBTB3 effectively downregulated wild-type HIF1α, but had little effect on the hydroxylation-defective mutant P564A (Supplementary information, Figure S2C).

We looked for functional annotations that could characterize the probe-sets that were downregulated in tumors, compared to the other predicted targets that were not effectively downregulated.

They reported that both analogs effectively downregulated PI3K/PDK-1 dependent signaling at low micromolar concentrations, consistent with the effect of the drugs as selective PDK-1 inhibitors.

PLD effectively downregulated aspartate transaminase (AST), alanine aminotransferase (ALT), total cholesterol (TC), and triglycerides (TG) in liver.

Moreover, paeonol effectively downregulated brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB) and Nuclear factor-κB (NF-κB) in hippocampal.

Effective treatment of arthritic conditions will benefit from a strategy that can simultaneously target multiple cellular signalling pathways to effectively downregulate inflammation in chondrocytes without adverse systemic effects.

Treatment with Candesartan (2 mg/kg per day) could effectively downregulate Smad3 and fibronectin accompanied by upregulating of Smad7.

A highly accessible site on this mRNA was identified, and a ribozyme targeted to this site was demonstrated to effectively downregulate NCOA3 function in cells.

In addition, rHDL/CD-PEI/p53 complexes co-delivering CD and p53 gene achieved synergistic angiogenesis suppression by more effectively downregulating the expression of vascular endothelial growth factor (VEGF) messenger RNA (mRNA) and protein via different pathways in vitro.

Consistently, quantitative real-time PCR and ELISA analysis also showed that NdpA (L21E) couldn't effectively downregulate IL8 expression in A549 cells during K. pneumoniae infection (Fig. S5C and S5D).