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That is, JAK2 V617F can overcome the requirement for a ligand-induced conformational change and effectively be capable of signaling from various relative conformations of a dimeric cytokine receptor, while in the wild-type scenario a ligand-induced conformational change in the receptor transmembrane and cytoplasmic domains is required, leading to the proper active conformation.
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But for the system to work effectively, buyers must be capable of making knowledgeable decisions.
And it may be because chickens that have spent all the early part of their lives in a building are effectively engineered not to be capable of going outside.
In addition, these algorithms need to work effectively across heterogeneous environments and be capable of managing and operating in highly dynamic environments.
Alternatively, phosphors and certain semiconductor NCs such as CdSe/ZnS core/shell quantum dots are known to be capable of effectively converting high-energy photons to low-energy ones, and consequently, white light sources can be produced.
While he knew that he would be capable of effectively using them, he was also aware that none of his pilots were trained in the use of a gun or dogfighting.
Furthermore monotherapies may not be capable of effectively reducing Aβ plaque load.
In addition, young adults may not be capable of effectively advocating for themselves in the adult health care system.
A single agent alone may not be capable of effectively modifying the complex pain mechanisms that underlie PHN.
While the exogenous administration of miRNAs (or "antagomirs") have been shown to be capable of effectively regulating targeted oncogenes and tumor suppressor genes in specific cellular contexts [ 30], the indirect effects of perturbing miRNA levels remains difficult to predict.
The original series of non-NSAID-derived GSMs were recently shown to be capable of effectively attenuating β-amyloid deposition in a transgenic mouse model of AD following chronic administration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com