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Inspired and motivated by the unique advantage of drug self-constructed nanoparticles and potential merits of therapeutic agent with a dual role, one would envisage the possibility of designing a self-targeting and high-drug loading nanomulti-drug to simply achieve the more effectively and specifically cell-targeting effect and cell-killing efficacy against cancer cell.
It is also unclear how tissue-specific signaling pathways could be effectively and specifically targeted.
Western blot analysis confirmed all the 12 RNAi target genes were effectively and specifically silenced within 48 h by the respective specific RNAi (Fig. 3B, 4B, and data not shown).
The PNA probe can combine to target DNA sequences more effectively and specifically than a DNA probe.
The 111In radioligands effectively and specifically internalized into rsst2A-expressing AR4-2J cells with [111In]AT2S internalizing faster than [111In]AT1S.
Taken together, our data demonstrated dCas9-SunTag-VP64 system can effectively and specifically reactivate latent HIV-1 transcription, suggesting that this strategy could offer a novel approach to anti-HIV-1 latency.
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"So we have engineers who are interested in nanotechnology, for delivering cancer drugs more effectively and more specifically to cancer cells — that's an engineering problem," he said.
Taken together, these results suggest that our PolyA-Pull construct effectively enriches tissue-specific mRNAs and specifically binds polyA+ RNAs.
This pseudotype vector effectively reduces LAMR expression and specifically targets tumors in vivo.
The secret agreement allowed Altus to effectively control Executive through MAAF and specifically provided that the arrangement was to be kept secret from "any and all third parties," the suit says.
Figure 3D shows that the velocity of cancer cells moving on fibronectin, as well as on poly- L-lysine, was significantly slower than that on collagen I. Thus, collagen I facilitates cell adhesion, and specifically and effectively promotes the motility.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com