Sentence examples for effective trail from inspiring English sources

Therefore, alternative non-toxic sensitizing substances without such severe side effects are needed for an effective TRAIL based therapy of tumor patients.

The introduction of individual and groups of variables into a series of regression models provides improved understanding and insights regarding the relative influence of these variables, informing the selection of more effective trail management actions.

Withanolide E was the most effective TRAIL sensitizer, but least toxic, of the withanolides assessed.

A summary of effective TRAIL sensitizers from the screen, along with their corresponding efficacies for reducing cancer cell viability, is provided in Table 1.

Withanolide E was also a very effective TRAIL sensitizer for two other renal carcinoma lines, but only modestly affected untransformed human renal epithelial (HRE) cells, even at very high TRAIL concentrations.

Having shown that PIK-75, a potent inhibitor of p110 α, is a very effective TRAIL sensitizer, we next investigated whether specific inhibition of the p110 α isoform of PI3K was capable of breaking TRAIL resistance in cancer cells and, hence, responsible for the PIK-75-mediated effect.

An effective trailing exit to limit losses must be carefully planned and is far from simple.

Here are three suggestions on how to implement an effective trailing exit strategy: –Identify the direction of the current trend.

Yet, we previously showed that there is a large therapeutic window which allows effective TRAIL-based cancer therapy [ 10].

As robust cell death induction in transformed cells is crucial for effective TRAIL-based anti-cancer therapy, we concluded that interfering with the PI3K/Akt signaling axis or CDKs is most probably insufficient to fully exploit the therapeutic potential of TRAIL in PIK3CA-mutant CRC cells.

This 40-minute trail may be one of the most cost-effective trails in town.