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Previous studies [2], [3] have suggested that coherent oscillations could be used in the brain as an effective time frame regulating neural coding.
Three to 12 months beforehand is a reasonable and effective time frame if the course targets international trainees, otherwise a shorter period may suffice.
Our results indicate that while VEGF has an indubitable neuroprotective effect, its therapeutic potential for halting or delaying the progression of motor neuron loss in ALS would likely have a short effective time frame.
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Because of the chronic and variable nature of OA, new methods are needed to optimise the selection of patients for trials and as outcome measures - in short, any route by which the long course of OA can be abbreviated into a more cost-effective time frame.
Despite the upfront costs for the device and implantation, our analysis showed that SPG stimulation has the potential to be cost-effective in time frames as short as 3 years, and to reduce overall costs to payers in timeframes greater than 5 years, primarily through the reduced need for rescue medications, but also by means of its observed preventive effects.
Data were acquired from an image plane containing the liver and umbilical cord using a 10-kHz absolute frame rate with M = 5 transmission angles spanning ±10 degrees which yielded an effective slow-time frame rate of 2 kHz after beamforming and compounding.
The full image sequence is available as Movie 2. With the imaging plane showing the embryonic heart and umbilical vessels, data were acquired using an absolute frame rate of 20-kHz with M = 5 transmission angles spanning ±10 degrees which yielded an effective slow-time frame rate of 4 kHz after beamforming and compounding.
In this model, treatment of acute P. aeruginosa-induced pneumonia either by simultaneous or, even more important, therapeutic PiMT was highly effective within a short time frame.
A pilot study marshals sequencing resources and broad expertise to analyze patients' tumors in a cost-effective and clinically relevant time frame.
An additional concern about this method is the short time frame for effective application: a gradual decline in signal strength has been found when using an incubation time of the phage with Y. pestis longer than 90 min [39].
The time frame for effective ALN treatment following injury remains to be determined.
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