Sentence examples for effective release of the from inspiring English sources

This work demonstrated that this innovative type of clickable prodrugs entered cancer cells and showed restored anti proliferative properties attributed to the effective release of the HDAC inhibitors.

The key problem in venting is the appropriate design of the vent area necessary for an effective release of the material.

Finally, the incorporation of naproxen into the nanotubes was accessed by fluorescence measurements and drug release studies were performed, revealing that the electrostatic linkage ensures effective release of the drug in the acidic pH typical of inflamed cells, while maintaining the SNT-drug conjugates stable at the typical bloodstream pH.

Coincubation of (GPO)10 with Cy2-proMMP-2 or subsequent treatment of ECM-bound Cy2-proMMP-2 with (GPO)10 either prevented gelatinase binding or promoted effective release of the sequestered enzyme.

Although it may not provide effective protection against lysosomal degradation, minimal encapsulation may be beneficial to the gene delivery system, as it requires little energy for effective release of the pDNA in the cytosol.

Three histidines (H3) were introduced in the molecular design to offer the buffering effect upon protonation of the imidazole ring inside endosomes or lysosomes, which has been reported to induce the rupture of the endosomal/lysosomal membrane for the effective release of the entrapped conjugates into cytosols.

When E. coli/pNC1, which produces β-glucosidase and accumulates it in cytoplasm, was exposed to PEF, the most effective release of this enzyme was achieved in the cell suspension of 5% glycine and 15% PEG solution under 10 kV/cm and 280 J/ml of a PEF in a needle plate electrode chamber.

In those settings, non-responding advanced tumors may have more aggressive features with high cell turnover and a better blood supply leading to more effective release of nucleosomes into the blood or a less effective elimination of nucleosomes from the circulating due to a weakened or impaired immune system.

PEG5K-S-S-FTS2 retained the FTS biological activity well, which was attributed to an effective release of FTS from the conjugate following intracellular delivery.

Together with the effective cleavage observed above, we believe that the additional 5 residues in LHEEL-CLV3p17 lead to effective release of CLV3p12, and hence the equivalent activity as CLV3p12.

Polizzi et al. [ 63] showed that nitric-oxide can be stored by covalent linking with polyamine-stabilized gold nanoparticles and allowed for effective release of nitric oxide from the water soluble nanocontainers.