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Subsequent studies identified the dose of BCG and effective regimens that could be used to avoid undesirable vaccination side-effects.
Effective regimens vary individually.
Even effective regimens can be complicated and must be followed for a lifetime, which could be 50 years or longer for young infected people.
The rarity of this type of cancer, which accounts for only 1 4% of all ovarian tumors37, hinders the design of clinical trials to identify effective regimens.
For those patients who need treatment, highly effective regimens have been developed over the past several years, producing objective response in more than 90% of CLL patients.
Standard chemotherapy for poor-prognosis metastatic nonseminoma has remained bleomycin, etoposide, and cisplatin (BEP) for many years; more effective regimens are required.
Finally, we provides advice regarding trial design using "best shot" pilot studies to efficiently identify tentative effective regimens which are then confirmed in randomized trials all the while minimizing patient risks and drug exposure.
In spite of the recent introduction of two new drugs (delamanid and bedaquiline) and a few repurposed compounds to treat multidrug-resistant and extensively drug-resistant tuberculosis (MDR- and XDR-TB), clinicians are facing increasing problems in designing effective regimens in severe cases.
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Measures which are being used range from sending laboratory test results by email, home delivery of the drugs to the patient, which is exempted from VAT in the UK, to using the most cost-effective regimens [13].
However, starting PLHIV on cost-effective regimens earlier, will maintain them in better health, resulting in the use of fewer health or social services and thereby generating fewer treatment and care costs, while enabling them to remain socially and economically active members of society.
Cost-effective regimens are also advantageous.
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