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This approach has previously been shown effective on gene expression data [ 76].
In another study in mice, which were given a 5-week continuous dose of radiation at 2 μGy/min (cumulative dose 10.5 cGy, which was previously shown to be effective on gene expression as a single acute dose [ 6]) there was no significant change in gene expression.
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Topotecan and irinotecan have highly similar effects on gene expression.
Genetic effects on gene expression across human tissues.
"Genetic effects on gene expression across human tissues" (Nature).
In addition, comparison of the C9433 effect on gene expression to signatures caused by over-expression of genes identified 11 genes in the top 10th percentile (i.e. their overexpression caused a similar gene expression profile).
Krikun G, Schatz F, Taylor R, Critchley HO, Rogers PA, Huang J, Lockwood CJ (2005) Endometrial endothelial cell steroid receptor expression and steroid effects on gene expression.
These "downstream" effects on gene expression -- apart from the DNA mutations -- might be vulnerable to innovative drugs.
Little is known about the effect of microgravity on gene expression, particularly in vivo during embryonic development.
Figure 2 Effect of atrazine on gene expression.
The Cancer Genome Work Bench (CGWB) is an effective tool with a focus on gene expression and mutations, CNV, and methylation [10].
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CEO of Professional Science Editing for Scientists @ prosciediting.com