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Robust features are its large width on a logscale and the fact that most probability mass is between effective neutrality and lethality [ 46, 47].
Since neutral mutations are expected to be those with s ≤ 1/ Ne, the threshold for effective neutrality is probably very low and unlikely to be captured by any existing experimental method.
"Going to backup" does not affect the total number of generations of MA (i.e., Gmax); it does affect the effective population size (N e) and thus the parameter of effective neutrality (4 N es < 1; see discussion in Baer et al. (2010).
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However, in less extreme cases, recessivity may be strong enough to reduce the effects of a complete gene knockout to effective selective neutrality (N e sh < 1).
A federal lawsuit filed by Verizon has forced the FCC into a corner by creating a standard under which effective net-neutrality rules which ensure all internet traffic is treated equally can only be reached, according to most analysts, by classifying the internet as a "common carrier," or in other words, a public utility.
We find that several measures of neutrality are effective at separating structured RNAs from decoy sequences, including both shuffled alignments and flanking genomic sequence.
Somalia's catastrophe is about how "humanitarian space" – the principles of neutrality crucial to effective intervention – has been destroyed by US policy in Somalia since 9/11.
As all major broadband providers and their trade groups have conceded, the FCC already has sufficient authority under Section 706 to adopt rules that address any practices that threaten harm to consumers or competition, including authority to prohibit 'paid prioritization.' For effective, enforceable, legally sustainable net neutrality rules, the Commission should look to Section 706".
In this work, we show that RNA sequence neutrality is an effective feature for machine learning approaches to classify structured RNAs from various decoy sequences.
Both the skyline plots and the mismatch reconstructions indicated a recent decrease in the effective population size (although the neutrality tests were not significant).
We tested for past sudden changes in effective population size using Fu's test of neutrality [ 73], which detects departures from neutrality in scenarios characterized by an excess of rare alleles and young mutations in sequences not subjected to recombination.
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