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It is cleavage-complex stabilisation that has been found to be the most effective mode of action of inhibitors of gyrase and other topoisomerases (Anderson and Osheroff 2001; Drlica et al. 2009).
On the other hand, the TFs that negatively regulate hydrolytic enzyme gene transcription, such as ACE1 and CREI, showed a lower level of expression, compared to the positive-acting TFs, or were not transcriptionally modulated depending upon the carbon source, suggesting that these TFs may act in a cooperative manner or have a more effective mode of action.
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Is it an effective mode of communication, the pop song?
Make sure you have an effective mode of transportation.
Structured social network relations are the foundation of any economic action; therefore, effective modes of company governance must take into account the social network relations between economic agents (Williamson 1975; Granovetter 1985).
Subsequently, mode-of-action and pharmacokinetic information were incorporated.
Mode-of-action models strengthen science in two important ways.
Ultimately, I'm interested in effective modes of communication.
Are the critical effect(s) and mode of action understood?
Therefore, new enediynes would be extremely valuable assets in the development of safer, more effective ADCs with a validated mode of action.
Most of the ethno medicinal compounds were ignored by medical practitioners despite of their proven in vitro and in vivo antiviral properties due to lack of evidence on their mode of action, effective dosage, chemical composition and toxicity [ 10].
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CEO of Professional Science Editing for Scientists @ prosciediting.com